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[(28)-412.9(ga)20.7(ug)21(e)-422.1(i)0(n)19.8(j)0(e)19.4(c)0(t)19.6(o)0(r)20.8(s)-422.3(e)12.5(x)0(t)19.9(e)0(n)15.5(d)13(i)11.7(n)0(g)-413.3(2)0(.)19.3(5)-157.3(m)10.2(m)-419.2(be)21(yo)21.6(nd)-413.4(t)12.3(h)0(e)-413.6(e)0(n)20.7(d)]TJ
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(+)Tj
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[(ha)193.2(p)213.8(a)193.2(r)213(t)193.2(.)]TJ
5.0438 57.9085 TD
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[(Immediately)-260.8(after)-264.6(microinjections,)-263.2(a)-261.5(tastant)-263.8(delivery)]TJ
-.9984 -1.1847 TD
0 Tc
[(tube)-289.9(\(PE-10\))-287.2(was)-291.2(connected)-287.9(to)-289.5(oral)-290.7(cannulae,)-290.2(and)-291.9(rats)]TJ
0 -1.1795 TD
[(were)-201.5(placed)-203.5(in)-207.8(the)-199.5(test)-204.2(chamber.)-206.6(At)-200.8(30)-206(and)-204(45)-164.6(min)-202.8(post-)]TJ
0 -1.1847 TD
[(microinjection,)-348.5(a)-344.2(1)-167.6(mL)-348.6(volume)-349.7(of)-347.1(1%)-343.7(sucrose)-351.3(was)-348.2(in-)]TJ
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[(fused)-304.9(into)-305.9(the)-303(mouth)-304.4(for)-303.8(1)-167.6(min,)-305.5(based)-303.1(on)-304(previous)-307.2(re-)]TJ
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[(sults)-538.3(indicating)-541.9(hedonic)-540.7(reactions)-543.8(are)-536.7(enhanced)-543(by)]TJ
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[(anandamide)-236.7(at)-238.7(those)-240.8(timepoints)]TJ
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(21)Tj
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[(\).)-240.8(Orofacial)-237.7(reactions)]TJ
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[(were)-299.8(video)-303.3(recorded)-307(through)-301.5(an)-305(angled)-300.9(mirror,)-304.7(allow-)]TJ
0 -1.1847 TD
[(ing)-298.1(clear)-300.1(view)-299.7(of)-300.5(the)-297.8(rats)-301.5(mouth.)]TJ
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[(mo)4.6(tion)-254.4(by)-254.7(a)-260.2(b)4.6(linded)-254.8(observer,)]TJ
11.8259 0 TD
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[(c)5.2(e)0(du)5.7(re)5.2(s.)]TJ
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[(21)6.6(,28)6.6(,).9(29)]TJ
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[(er)-4.4(ed)-339.8(to)-339.1(be)-340.4(rhythmic)-335.2(mi)-4.9(dl)-4.6(ine)-335.2(t)]TJ
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[(o)4.6(n)-1(gu)3.9(e)-338.1(p)3.9(rotrusion)4.2(s)-2.1(,)-334.3(l)2.9(ateral)]TJ
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11.9811 0 TD
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[(li)-4.7(mb)-452.7(ai)-4.7(l).8(s,)]TJ
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[(30)6.6(,31)]TJ
10.959 0 0 10.959 378.3117 503.603 Tm
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[(alth)3.9(ough)-451.4(the)-452.6(l)2.2(ast)-452.8(t)2.5(hree)-447.4(have)-452.6(also)-451.3(been)]TJ
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8.2191 0 0 7.3052 413.1779 495.4959 Tm
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(32)Tj
10.959 0 0 10.959 423.0424 490.677 Tm
[(a)-4.1(s)-211.6(wel)-4.9(l)-211.8(as)-216.8(aver)-4.7(si)-5.2(on.)-212.8(N)-2.1(e)-4.4(u)1.3(t)-4.6(r).5(a)-4.1(l)-211.8(re)-4.4(-)]TJ
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0 -1.1795 TD
[(ioral)-464.1(t)1.8(esti)-4(ng,)-465(b)-2(rains)-463.9(w)4.3(ere)-463.6(s)-3.5(ec)]TJ
11.6655 0 TD
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[(Repeated)-514.3(measures)-515.1(\(drug,)]TJ
10.9671 0 TD
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[(ti)-3.9(me)-510.1(point\))-515.8(and)-514.7(m)-.3(ixed-)]TJ
-11.9655 -1.1847 TD
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[(model)-287.3(a)3.2(nalyses)-287.1(o)-1.1(f)-287.7(v)-1.7(ariance)-286.8(\()]TJ
11.024 0 TD
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[(ANO)4.9(V)-.9(As;)-288.4(b)-1.3(etween)-291.4(subjects)]TJ
-11.024 -1.1795 TD
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[(vari)-4.3(ables:)-196.3(sex,)-196.3(cannulae)-194.9(si)-4.3(te)]TJ
10.2584 0 TD
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[(\))-189.2(w)-.1(ere)-193.8(u)3.3(sed,)-190.1(with)-192.6(Greenhouse-)]TJ
-10.2584 -1.1847 TD
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0 -1.1795 TD
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[(o)3.9(l)-3(ated)-193.4(in)-187.9(Mauchlys)-189(t)-2.7(est.)-190.2(Po)3.9(st-h)3.9(oc)-188.7(co)3.9(mparisons)-189(e)-2.5(mployed)]TJ
T*
-.0148 Tc
[(Tu)3.4(keys)-313(H).3(SD,)-308.9(o)-1.1(r)-313(c)2.9(orrected)]TJ
/F11 1 Tf
10.7499 0 TD
0 Tc
(t)Tj
/F5 1 Tf
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[(-te)-3.7(s)-4(ts.)-356.9(P)-2.6(ri)-4.5(mar)-4(y)-349.7(analys)-4(es)-355.8(ex-)]TJ
-11.0395 -1.1847 TD
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[(ami)-3(n)3.8(ed)-306.9(total)-302.7(h)-1(edoni)-3(c)-302.3(or)-302.5(avers)-2.5(i)2.2(ve)-302.2(r)-2.5(e)3(actions)-302.5(t)-2.4(o)-301(s)-2.5(ucros)-2.5(e)-302.3(at)]TJ
0 -1.1795 TD
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[(both)-653.7(time)-649.8(points)-650(\(30,)-646(45)-167.7(min)-648.9(a)-2.8(ft)-3.3(er)-650(microinject)-3.3(i)1.3(on\),)]TJ
0 -1.1847 TD
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[(si)-5.7(nc)-4.9(e)-439.5(r)0(e)-4.9(a)-4.6(ct)-5.1(ions)-439.7(we)-4.9(re)-439.5(s)-5.2(i)-.5(mil)-5.4(a).6(r)-439.7(a)-4.6(t)-439.6(b)-3.7(ot)-5.1(h)-438.3(t).1(i)-5.7(m)-2.1(es)-439.7(a)-4.6(f)-.6(t)-5.1(e).3(r)-439.7(i)-5.7(nt)-5.1(ra)-4.6(-)]TJ
0 -1.1795 TD
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[(NAc)-209.8(m)-.1(icroinjections)-204.9(\(no)-208.6(m)-.1(ai)]TJ
11.1896 0 TD
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[(ne)206.4(f)210.7(f)210.7(e)206.4(c)211.6(t)-.7(o)212.8(f)-1.4(t)211.4(i)205.6(m)214.4(e)-.5(p)206.9(o)212.8(i)205.6(n)212.4(to)212.8(nh)212.8(e)206.4(-)]TJ
-11.1896 -1.1847 TD
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[(d)4.5(o)0(nic)-353(r)3.7(ea)4.3(ctio)5.2(ns)-348.1(afte)4(r)-353.3(N)1.1(Ac)-347.8(d)-26.5(r)-22.2(u)-21.4(g)-26.5(s)-22.2(;)]TJ
/F11 1 Tf
13.4192 0 TD
0 Tc
(F)Tj
/F5 1 Tf
8.2191 0 0 7.3052 463.7479 281.5936 Tm
.0107 Tc
[(1,)-5.8(9)]TJ
/F9 1 Tf
10.959 0 0 10.959 475.54 283.4078 Tm
0 Tc
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/F5 1 Tf
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[(3.7)3.8(6)-1.4(,)]TJ
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(p)Tj
/F9 1 Tf
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(=)Tj
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[(0)-5.2(.)-2.3(08)-5.2(4;)]TJ
-19.4149 -1.1795 TD
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/F9 1 Tf
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()Tj
/F5 1 Tf
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[(time)-706(p)3.2(o)-1.2(int)2.5(;)]TJ
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(F)Tj
/F5 1 Tf
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[(3,)8(27)]TJ
/F9 1 Tf
10.959 0 0 10.959 515.6219 270.4818 Tm
0 Tc
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/F5 1 Tf
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[(0)-5.2(.)-2.3(77)-5.2(4,)]TJ
/F11 1 Tf
-19.4149 -1.1847 TD
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(p)Tj
/F9 1 Tf
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/F5 1 Tf
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[(0)-4.2(.)-1.3(51)-4.1(9\),)-363.4(a)-4.8(s)-362.3(p)-4.5(rev)-4.5(i)-.7(ou)-4.5(sly)-366.6(r)-.2(e)-5.1(p).6(orted)-4.5(.)]TJ
8.2191 0 0 7.3052 463.9747 262.3748 Tm
.0176 Tc
(21)Tj
10.959 0 0 10.959 476.0503 257.4991 Tm
.0102 Tc
[(Nor)-365.6(w)4.3(as)-360.4(there)-365.3(a)]TJ
-15.0746 -1.1795 TD
[(main)-307.4(effect)-303.3(of)-309.1(sex)-308(\()]TJ
/F11 1 Tf
7.9563 0 TD
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(F)Tj
/F5 1 Tf
8.2191 0 0 7.3052 403.8235 242.759 Tm
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[(1,)8(8)]TJ
/F9 1 Tf
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0 Tc
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/F5 1 Tf
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[(0)-5.2(.)-2.3(13)-5.2(2,)]TJ
/F11 1 Tf
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(p)Tj
/F9 1 Tf
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/F5 1 Tf
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[(0)-4.6(.)-1.8(72)-4.7(6\),)-312.2(o)-4.3(r)-305.9(i)-6.4(nte)-5.6(r)-.7(ac)-5.6(-)]TJ
-14.3918 -1.1795 TD
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[(tions)-361.2(o)-2.7(f)-356.6(s)-4.2(ex)-360.7(with)-359.7(NAc)-360.9(d)1.7(r)-4.2(u)1.7(g)-360.3(\()]TJ
/F11 1 Tf
12.1983 0 TD
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(F)Tj
/F5 1 Tf
8.2191 0 0 7.3052 450.3684 229.7763 Tm
.0107 Tc
[(3,)-5.8(24)]TJ
/F9 1 Tf
10.959 0 0 10.959 466.2424 231.6472 Tm
0 Tc
(=)Tj
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[(1)5.2(.)2.9(66)5.2(4,)]TJ
/F11 1 Tf
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(=)Tj
/F5 1 Tf
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[(0.2)-3.9(0)1.2(1)-4(\))-.3(,)]TJ
-19.0631 -1.1847 TD
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[(so)-343.8(sexes)-345.3(w)-1.2(ere)-345(c)1.6(omb)2.8(i).8(ned)-344.5(f).8(or)-340.1(subsequent)-345.2(analyses)-345.3(\(al-)]TJ
0 -1.1795 TD
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[(though)-266.9(thi)-5.1(s)-263.2(st)-4.5(udy)-262.3(w)-1.9(as)-268.4(not)-268.3(p)1.4(ower)-4.5(ed)-267.6(to)-266.9(ident)-4.5(ify)-267.5(subtl)-4.7(e).9(r)]TJ
0 -1.1847 TD
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[(sex)-303.8(d)1.6(i)-4.9(fferences\).)-300.4(Si)-4.9(gnicance)-298.9(w)-1.7(as)-304.4(set)-304.3(a)1.4(t)]TJ
/F11 1 Tf
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(p)Tj
/F9 1 Tf
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()Tj
/F5 1 Tf
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[(0.0)3.8(5)-1.3(.)]TJ
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10.4607 0 0 10.4607 310.8472 166.8472 Tm
/Cs8 cs 1 scn
0 Tc
(Results)Tj
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0 -1.2357 TD
[(Anandamide-induc)7.4(ed)-303.7(hedonic)-296.9(hotspot)-298.6(depends)]TJ
0 -1.2411 TD
[(upon)-297(endogenous)-297.4(opioids)]TJ
/F5 1 Tf
10.959 0 0 10.959 310.8472 128.0126 Tm
0 0 0 rg
[(Anandamide)-224.7(by)-226.7(itself)-222.5(microinjected)-227.9(into)-223.1(the)-225.4(rostrodor-)]TJ
0 -1.1847 TD
[(sal)-263(NAc)-258.3(shell)-263.5(hedonic)-261.4(hotspot-enhanc)5.7(ed)-264.2(hedonic)-261.4(reac-)]TJ
0 -1.1795 TD
[(tions)-381.6(to)-387.8(sucrose,)-381.7(whereas)-385.2(anandamide)-386.7(microinjection)]TJ
T*
[(in)-249.2(prefrontal)-246.7(cortex)-249.9(or)-248.2(in)-249.2(the)-246.1(rostral)-248.8(pole)-248.8(of)-248.8(NAc,)-247.3(ante-)]TJ
0 -1.1847 TD
[(rior)-296.8(to)-294.7(the)-297.8(hotspot,)-296.3(did)-298.5(not)-296.9(\(Drug)]TJ
/F9 1 Tf
13.7813 0 TD
()Tj
/F5 1 Tf
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[(cannula)-298.2(site)-297.9(inter-)]TJ
-14.5004 -1.1795 TD
(action:)Tj
/F11 1 Tf
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(F)Tj
/F5 1 Tf
8.2191 0 0 7.3052 350.7589 61.3984 Tm
(1.47,23.52)Tj
/F9 1 Tf
10.959 0 0 10.959 385.5684 63.2692 Tm
(=)Tj
/F5 1 Tf
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(5.625,)Tj
/F11 1 Tf
2.7987 0 TD
(p)Tj
/F9 1 Tf
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(=)Tj
/F5 1 Tf
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[(0.016\))-451(\(Fig.)-451.4(1a,)-449(b\).)-449.6(NAc)]TJ
ET
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[(\(f)-83.4(\))]TJ
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[(anandam)-7.5(ide,)]TJ
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5.7361 0 TD
(\(g\))Tj
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[(naloxone,)-309.9(or)]TJ
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5.5255 0 TD
(\(h\))Tj
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[(ananda)-9.7(mide)]TJ
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[(naloxone)-307.7(in)-300.2(indiv)-9(idual)-304.5(rats.)-305.1(NAc,)-303.9(nuc)-7.8(leus)]TJ
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7.9702 0 0 7.9702 62.022 755.2061 Tm
(Mitchell)Tj
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[(,)-304.1(e)0(t)-293.7(al.;)-304.2(Cannabis)-291.4(and)-299.8(Cannabin)10.8(oid)-299.8(Research)]TJ
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[(2018,)-295.3(3.1)]TJ
-21.567 -1.2021 TD
[(http://onl)9.4(ine.liebertpu)9.7(b.com/doi/1)9.2(0.1089/can.2)8.4(018.0021)]TJ
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